James M. Wells, Ph.D.'s picture
James M.
Wells, Ph.D.
Professor, Division of Developmental Biology
Co-Director, Pluripotent Stem Cell Facility
Director for Basic Research, Division of Endocrinology

Cincinnati Children's / University of Cincinnati

Title of Abstract

Human Pluripotent Stem Cell-derived Gastrointestinal Organoids as New Models to Study Human Organ Development, Digestive Diseases and Diabetes

Research Interests

The focus of the Wells team's basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.


Cincinnati Children's Hospital / University of Cincinnati