Julie Phillippi, Ph.D.'s picture
Julie
Phillippi, Ph.D.

University of Pittsburgh

Biography

Dr. Julie Phillippi is Assistant Professor of Cardiothoracic Surgery (primary appointment) and Bioengineering (secondary appointment). PhD (Biological Sciences), Carnegie Mellon University, 2005. Dr. Phillippi’s research scope broadly encompasses cell-extracellular matrix (ECM) dynamics using tissue-engineered approaches to study, diagnose and treat cardiovascular disease.  Of immediate interest is the presence of local stem cells within distinct microenvironments of the aorta and their contribution to the development and progression of aortic aneurysm. Dr. Phillippi’s projects are carried out using human aortic tissue specimens and cell populations isolated from surgical patients of the Center for Thoracic Aortic Disease at the University of Pittsburgh Medical Center. Dr. Phillippi and her colleagues within the Thoracic Aortic Disease Research Laboratory are working to characterize the influence of distinct cell populations within the ascending aorta and the role of oxidative stress pathways on aortic wall architecture, strength and propensity for aortic disease. The ultimate goal of her work is to establish novel diagnostics and risk mitigation for patients affected by thoracic aortic disease and to develop new less-invasive treatment options that aim to prevent dilatation and/or invoke reverse remodeling of the aortic wall. Dr. Phillippi is affiliated faculty of the McGowan Institute for Regenerative Medicine and the Center for Vascular Remodeling and Regeneration. For more information, visit http://www.mirm.pitt.edu/thoracicaorticresearch